You could, but why?: Saffron has known antidepressant effects which are close to those of Imipramine & prozac: http://www.Ncbi.Nlm.Nih.Gov/pubmed/17174460?Dopt=abstract my question is whether you want to use saffron for this, or for another reason? The trials only lasted 22-26 weeks -- longer use or higher doses might not be safe. Saffron poisoning can result in jaundice, vomiting, vertigo, bloody diarrhea, etc.
Answered 12/7/2017
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