A member asked:

What's the difference between taking prednisone once a day or multiple times a day? why spread it out?

2 doctors weighed in across 2 answers
Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

The effect is not different for single or divided dose but the stomach tolerates divided dose better in case of very high dose.

Answered 2/28/2022

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Many yrs ago, a study from Johns Hopkins Hospital noted a substantial decease in steroid side effects when ingested once daily as contrasted to twice or thrice daily

Answered 2/28/2022

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