What does persistent abnormality in igg kappa with slight increase in kappa light chains and m spike mean?

It means you need to have a good medical history taken and a good physical exam done and then all of your labs looked at by same Dr, So you all can figure it out, The best way to get medical information on complex issues like Igg is to pay $20 for a 1 month subscription to uptodate.com and then read all they have about Igg etc. Then discuss with your team.

Elevation of kappa light chains in the serum&probably in the urine, combined with an M spike in the immunoelectrophoresis is suspicious of AL amyloidosis or multiple mye!oma caused by a clone of abnormal plasma cells in your bone marrow. You don't mention the level of kappa light chains in your serum or the kappa/lambda ratio which are crucial to know. I recommend consulting an oncologist hematolo