Although highly unlikely to experience significant drug drug interactions, some combinations are problematic when one uses melatonin. You do not reveal the Hypertension medicines, so we cannot comment further.
Answered 9/2/2021
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There are studies that suggest melatonin may affect certain hypertension medications and cause an increase in blood pressure. The potential for melatonin to affect blood pressure and by how much would depend on the specific hypertension medication.
Answered 9/7/2021
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