A 56-year-old female asked:
Can i take 8mgs zofran and 10mgs domperidone together?
2 doctor answers • 3 doctors weighed in
Dr. Donald Colantinoanswered
Internal Medicine 63 years experience
I don't recommend this combination. Domperidone has been banned in the US because of fatal cardiac arrhythmias seen in elderly cancer patients. Intravenous zofran also demonstrated prolongation of the QT interval on EKG which can provoke dangerous arrhythmias. As you see combining these two meds can be hazardous & would be best used in a monitored setting for seriously ill chemotherapy patients
Answered Aug 19, 2021
Dr. Silviu Pasniciucanswered
Internal Medicine 29 years experience
Always take meds as prescribed. Domperidone is not approved for common use in US due to cardiac side effects that can overlap with Zofran’s and creating a drug-drug interaction to be avoided if possible. Your current prescriber remains best to clarify as having a clinical context to your question.
Reviewed Aug 20, 2021
Last updated Aug 20, 2021
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