Can i take a fioricet and zofran together?

Yes: It is prudent to limit Fiorcet use, please keep your provider involved. If pregnant. Zofran is typically not the first choice for anti-emetics especially in early to mid pregnancy.

Usually, but: There is a moderate potential for clinically significant interaction per Drugs.Com drug interaction checker. "Using acetaminophen together with butalbital may alter the effects of acetaminophen and cause serious side effects that may affect your liver."