It has been stated in medical literature that oral l-glutamine supplementation cannot cause excitoxicity due to astrocyte function but can higher doses cause excitoxicity in people with bipolar due to reduced astrocyte protective function?

Glial cells are affected in bipolar disorder(BD) major depression and schizophrenia.sfunctional astrocytes are noted in BD but particularly detoxing is affected, is not clear. Glutamine level is lower in BD. Oligodendrocytes change more uniformly. Lithium’s target is astrocytes.. A study is needed to be found or conducted to answer your question.