The mean elimination half-life of metoprolol is 3 to 4 hours; in poor CYP2D6 metabolizers the half-life may be 7 to 9 hours. It takes 4 half lives to be out of your system. Therefore, it a poor metabolizer would be rid of the drug in 28 to 36 hours. Approximately 95% of the dose is excreted in the urine.
Answered 7/9/2021
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