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A member asked:
If my grandma had breast cancer at 42 bc of brca (im not sure she had that) would my dad have had prostate cancer? hes 74 and has had an mri and biopsy and they thankfully found nothing but enlarged prostate. what are the chances he still has brca?
4 doctors weighed in across 2 answers
Because your grandma had breast cancer before 50 so you assume she might have BRCA 1 or 2 mutations and you dad may inherit that gene. Assume that your grandma had these mutations and your dad inherits this mutated genes, so he is at risk for high-grade prostate cancer. Biopsy is negative so BRCA (+) or (-) doesn't mean anything. Just follow PSA level and if there is a sudden spike, biopsy again.
Answered 6/17/2021
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BR CA gene mutation can be transmitted to both male and the female offspring of a BRCA carrier. However the frequency/prevalence of this gene in the general population is not more than 5%. Moreover only 50% of the careers transmit the gene to their children. I hope this information will allow you to understand what you wanted to know.
Answered 6/19/2021
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