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A 29-year-old male asked:

Can an impaired bone marrow affect hiv testing. will it delay seroconversion in hiv? 8 months exposure negative 4 generation combo lab test?

2 doctor answers • 2 doctors weighed in
Dr. Donald Colantino
Dr. Donald Colantinoanswered
Internal Medicine 63 years experience
I think that if you have a bone marrow disease that impairs your production of immunoglobulins it's possible to have a false negative HIV test. Examples of such bone marrow diseases would be multiple myeloma and primary amyloidosis where low IgG,IgA&IgM immunoglobulins are common. A hematologist or infectious disease specialist could provide more information on this matter,however.
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Answered May 30, 2021
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Dr. Gurmukh Singh
Dr. Gurmukh Singhanswered
Pathology 51 years experience
What is the evidence for impairment of bone marrow? Unless you have inherited immune deficiency that may have interfered with antibody formation, a negative Gen 4 test at 8 months after exposure excludes HIV.
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Answered May 30, 2021
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Last updated May 30, 2021

Found in:

Bone›Human immunodeficiency virus

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