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A 29-year-old male asked:

Can an impaired bone marrow affect hiv testing. will it delay seroconversion in hiv? 8 months exposure negative 4 generation combo lab test?

2 doctor answers2 doctors weighed in
Dr. Donald Colantino
Internal Medicine 63 years experience
I think that if you have a bone marrow disease that impairs your production of immunoglobulins it's possible to have a false negative HIV test. Examples of such bone marrow diseases would be multiple myeloma and primary amyloidosis where low IgG,IgA&IgM immunoglobulins are common. A hematologist or infectious disease specialist could provide more information on this matter,however.
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Dr. Gurmukh Singh
Pathology 51 years experience
What is the evidence for impairment of bone marrow? Unless you have inherited immune deficiency that may have interfered with antibody formation, a negative Gen 4 test at 8 months after exposure excludes HIV.
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Last updated May 30, 2021


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