Ive been on 50mg of quetiapine to help me sleep for a couple months now its been going good but suddey i'm having a new terrible headache that subsides with constant pain meds, severe derealization and confusion could it be a bad reaction to the med?

Side effects: Per Drugs.Com, confusion & depersonalization have been reported in 0.1% to 1% & headache has reported in up to 21% of people taking it.

Frequent ha's: Quetiapine does have a high incidence of triggering headaches, and this could be dose related or idiosyncratic causing potential to find an alternative medicine. The cognitive-behavioral issues could likewise be an adverse event. Contact your doctor, as using medication to solve the side effects of the original medication could be a "blind alley".