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A member asked:
Is glutamate excitotoxicity a possible complication of coming off of a benzodiazepine too quickly? i know i shouldnt come off abruptly as it would lead to seizure but where exactly would excitotoxicity fit in? id greatly appreciate an answer please?
A doctor has provided 1 answer
DON"T STOP ABRUPTLY: I think I answered this already. Interesting but need more info. Like how much benzodiazepine and which one? Best to taper off and then no problem Abrupt withdrawal from a sufficient dose can lead to seizures and possibly death so consult a doctor to do this safely and do not get drugs off the street. Prescription only.
Answered 11/3/2020
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People also searched for:
If I was to suffer from excitotoxicity after withdrawing from a benzodiazepine medication, what would be a sign that it had occurred? Would a seizure be one, indicating the abundance of glutamate? Wikipedia doesnt offer a lot for BDZ wd particularly?
In the event of excitotoxicity occurring after withdrawing from a benzodiazepine, would excitotoxicity occur before or after a seizure occurs, i.e. would a seizure indicate that the glutamate concentration had reached excitotoxic levels?
Could glutamate excitotoxicity really occur after abruptly withdrawing from a benzodiazepine and, if so, is there any way to be able to tell that it occurred, such as a seizure indicating excess glutamate? Would a seizure be necessary as a precursor?
What situations lead to excitotoxicity? Is it a result or cause of seizures and can it happen during benzodiazepine/alcohol withdrawal or would a taper prevent this?
Can benzodiazepine withdrawal cause brain damage from neuronal overexcitation during withdrawal (not including through seizures) or in any sense or would the brain be ok? Would I be able to receive an explicit answer to this?
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