Edema: Edema is a side effect of amlodipine and it would be exaggerated if associated fluid retention from hormonal factors or excessive salt use is operative. There should be no associated calf pain, however, and I advise an ultrasound study to exclude phlebitis. Adding low dose diuretic or changing from amlodipine to another antihypertensive medication is an option to avoid ankle edema.
Answered 10/22/2020
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