It should not: nausea is a common side effect of estrogen in high dose. If she vomited immediately the dose should be repeated however 5 hours is enough to get systemic absorption, and the vomiting is likely a symptom of that. That said EC effectiveness is not 100 % and decreases significantly 48-72 hours after unprotected intercourse although it may be effective up to 5 days.
Answered 7/30/2020
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