A member asked:

Is narcolepsy a genetically inherited medical problem?

3 doctors weighed in across 2 answers
Dr. Christopher Wilson answered

Specializes in Sleep Medicine

Sometimes: It may be genetic sometimes. I have a couple families in my practice.

Answered 5/12/2013

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Yes for Some People: Most patients with narcolepsy with cataplexy have a genetic marker called hla dqb1*0602. However, many people without narcolepsy also this same marker. As such, simply having the marker is not sufficient to cause the condition. The current thought is that in narcolepsy an infection triggers the immune system to attack cells in the brain which secrete a chemical (orexin) needed to keep you awake.

Answered 10/4/2014

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