A member asked:

If my grandma have down syndrome and me and my parents don't, is it possible that my child have down syndrome?

5 doctors weighed in across 2 answers

Yes, but depends...: Down syndrome caused by a translocation can run in families. It is possible for your grandma to have had this (and had down syndrome) and passed the translocation to your mother (who passed it on to you), but neither one of you is affected. Under certain circumstances, you can pass translocation to your child and they get down syndrome. Tests are available to see if you carry a translocation.

Answered 12/10/2013

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Unlikely: The traditional 21 ds female is capable of having healthy babies and at least half would not have ds. Those healthy babies would not have more than 1% risk having a ds kid nor would their kids. Less than 2% of ds patients are balanced carriers of an extra piece or a 21, and the chance that they would have any normal kids (your parent) approaches zero.

Answered 8/10/2013

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