Hard to guess: Claritin (loratadine) is a once-a-day medication, and does wear off somewhat by night time. Regarding cold medications for example... if Nyquil, with its own antihistamine, is taken at night time, a person would be taking 2 antihistamines, which may or may not be a problem. Each person is different. His doctor can evaluate to see if there anything serious going on.
Answered 1/3/2020
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