Best medication for plaque psoriasis. i have tried almost everything?

Oral or shots: If it is localized a compound of lcd and salicylic acid can help. If it is extensive methotrexate, soriaitane or a biologic such as Enbrel (etanercept) will work, although results vary by individual.

Sunlight: Hi there, i'm assuming if you've "tried everything, " that would include most topical and systemic medications. One of the best treatments for plaque psoriasis is sunlight, as the uv rays can really make a big difference. Some of the vitamin a analogues are helpful as well, as these are specialized topical creams. If you haven't used an option from that group, i'd also give it a try. Take care.