Is it a bad idea to pop a blister on your hand?

Hand blisters: If the blister is painful, and not caused by a burn releasing the blister fluid and letting the blister dry out while maintaining good hygiene is one way to treat this. It is a bad idea if it cant be done in a clean environment or if there is a burn. Burn blisters need additional care. Burn blisters are typically second degree burns and further skin loss or infection can complicate treatment.