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A 33-year-old female asked:

Highly elevated ana (1:640, but neg for all ai diseases) 1 month ago; however, retested yesterday (antinuclear ab elisa) now showing negative (0.4 u). new test false negative since not using ifa? if still highly +, would have elisa likely shown +?

3 doctor answers6 doctors weighed in
Dr. Gurmukh Singh
Pathology 51 years experience
Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, it is not a good idea to chase lab results. If you do not have any symptoms, do not worry about the lab results. Just to be safe, avoid direct exposure to sun. Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex.
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Dr. Alvin Wells
Rheumatology 44 years experience
Abnormal labs: What symptoms were you're having that warranted ANA testing? This testing is only done to confirm diseases such as lupus, scleroderma, and other autoimmune diseases. The levels may fluctuate as your results indicate a may represent other underlying causes. I would not recommend repeating these levels unless she developed hair loss, oral/nasal ulcers, facial rash. I can do a consult if desired.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. John Goldman
Rheumatology 57 years experience
Agree need IFA: Agree the lab needs to use IFA. The Elisa is a poor screening ANA. Why the Elisa was used is not clear. In fact a good lab wouldn’t screen with Elisa. The other ANA subsets are better for disease evaluation You rheumatologist is aware of this. Part of the answer depends on your full evaluation We see + ANA in a lot of other conditions perhaps including mono at times but this is not usual
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Dec 4, 2017

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