Controversial: Some say that the risk of cardiovascular disease for people with Frank's sign is not significantly elevated. There appears to be no association in people who have diabetes. For others, the risk may be increased from your baseline risk by up to 1.5 times. See this review of the studies for and against a risk: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448193/
Answered 6/30/2019
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