Can diabetes cause a hole in ones heart?

No: Diabetes does not cause a hole in a patient's heart, and a hole in one's heart does not lead to diabetes. They are separate and unrelated issues. However, if a woman has diabetes during pregnancy, her baby has a higher chance of being born with a hole between the chambers inside the heart. Thus, the answer is "sometimes yes" if the question is, "Can diabetes cause a hole in somebody else's heart?"