Will smoking weed while taking metronidazole and fluconazole have a side effect?

Yes: Weed will have side effects, with or without other drugs. Weed is a psychoactive drug and messes with your brain. Just because it may be legal, does not mean that it is harmless. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. Get HPV vaccine, if you are under 27 years of age.