Hubby has swelling all over body arms/legs/ankles. went to er. heart/kidneys/lungs all fine. no answer. gave anti inflammatory and sent home. benadryl helps but he can't stop it. must take every 6 hr. primary had no answer. out of town 4 work. help. ?

Go to ER: This calls for a second opinion if nothing else. If there is any problem with his breathing, go back to the ER NOW. If just a little uncomfortable, call the doctor who is on call for your vacationing primary. Best wishes

Options: Would follow up with a Rheumatologist. This sounds like one of a couple of rheumatological diseases. As it seems to have responded to anti-inflammatory. If not that then Allergist to assess for the reason he needs Benadryl, which can be sedating. I might try OTC Zyrtec, Allegra, or Claritin instead. These are 2 ideas but certainly I don't have all of the information.