A member asked:

How long does it take to feel any benefits of an increased dose of duloxetine going from 60mg to 120mg and if feel more medicated after starting the increased dose (head feeling 'buzzy') can this wear off over time?

A doctor has provided 1 answer
Dr. Edward Kuhnley answered

Specializes in Child Psychiatry

Duloxetine: a potent: serotonin/norepinephrine reuptake inhibitor (SNRI) antidepressant. Common side effects: dizziness, somnolence, fatigue. Response is individual but in general doses above 60 mg may not add benefit and time to response may take 2-4 weeks. Side effects often resolve within that time otherwise, if intolerable, dose reduction or medication change may be necessary. Inform prescriber. Best regards.

Answered 2/5/2019

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