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Edison, NJ
A 38-year-old female asked:

Repeated blood tests show i have very low complement c3 @ 41 and not sure is c4 @ 12 is also considered low. what tests should be done next?

2 doctor answers2 doctors weighed in
Dr. Thomas Namey
Rheumatology 49 years experience
An ANA profile with : An ANA reflex profile. Keep in mind that partial complement deficiencies are not uncommon. But you need to rule out a complement consuming disease, such as lupus.
Dr. Gurmukh Singh
Pathology 50 years experience
Any symptoms?: Why were these tests done? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it needs to be kept in mind that complement proteins are labile and if the blood specimen is not handled properly, it may give inaccurate results. Would be prudent to get retested at a reputable lab.

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Last updated Nov 28, 2018

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