A member asked:

Repeated blood tests show i have very low complement c3 @ 41 and not sure is c4 @ 12 is also considered low. what tests should be done next?

2 doctors weighed in across 2 answers
Dr. Thomas Namey answered

Specializes in Rheumatology

An ANA profile with : An ANA reflex profile. Keep in mind that partial complement deficiencies are not uncommon. But you need to rule out a complement consuming disease, such as lupus.

Answered 11/28/2018

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Any symptoms?: Why were these tests done? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it needs to be kept in mind that complement proteins are labile and if the blood specimen is not handled properly, it may give inaccurate results. Would be prudent to get retested at a reputable lab.

Answered 5/23/2017

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