Depends: Benadryl is sedating and interacts with alcohol and other sedating meds. 25mg is usually a good starting point. Always read and follow the directions provided with any otc medication. Also recommend a long-acting medication such as cetirizine for sustained effect when treating new hives) Notify the treating physician and, if hives occur in other circumstances, see an Allergist.
Answered 9/4/2017
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