How long does the drug methotrexate take to give a reduction in pain levels..?

Uncertain: Methotraxate is not a pain reliever per se. It is prescribed in auto-immune inflammatory disorders and reduces pain indirectly by dampening the immune response and inflammation. It would depend on the disorder, response of your immune system, and the severity of disease. Wish you good health.

Weeks to months: Methotrexate works by reducing the function of the cells that are causing inflammation in the joint tissues. People with swollen and painful joints whose rheumatoid arthritis has not improved with initial, non-drug therapies will most likely be prescribed methotrexate for RA management. But it may take weeks to several months until the full benefits of methotrexate are noticeable

Methotrexate: It can take few weeks to moths for this medication to take effects as it works at a cell level to change its function. Key is continue unless you have side effects. Regular blood tests as recommended by doctor are important.

Methotrexate : Methotrexate is not a pain killer, it has anti inflammatory actions which are perceived as reduction in pain . Usually it takes few weeks to few months for the affect of methotrexate to be seen . Other painkillers like paracetamol, codeine, tramadol etc can be taken along with methotrexate for pain relief .