I am feeling repeated muscles tighten, spasm and relax when sleeping. felt most in sides, arms and legs. no hx of epilep, interaction between meds?

Hypnagogic jerk: A sudden muscle twitch while falling asleep is very common, and is called a hypnagogic jerk. There is a theory that this is a leftover reflex; a primate falling asleep whose muscles relax too much might fall out of a tree, and so we wake up to grab a limb. Drug interactions can cause or worsen lots of issues, and to help you figure that out would require a detailed history (including which meds?)