A member asked:

Migraine with aura started after starting zoloft. off 25 mg now for two weeks, still get but not as bad. had mri but no answers. normal? was on 2 mths

5 doctors weighed in across 3 answers

Time: Give some time to see if headaches improve. ON a bright note, I assume your MRI was "normal". But, if headaches persist, labs to screen for other medical causes would be justified.

Answered 4/11/2021

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High serotonin: Some people may be sensitive to the side effects of meds including SSRI antidepressants like Zoloft. The increase in serotonin stimulation in your brain may have triggered a migraine headache. Some neurotransmitters, hormonal changes & inflammatory agents can cause migraines. You may continue to experience headaches as your body gradually withdraws from the Zoloft.

Answered 4/11/2021

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You likely have a genetic susceptibility for episodes of classical migraine, and the Zoloft is but one potential provocateur. Other meds could be an issue. A neurologist could assist in "breaking up" this pattern by using preventative items, of which there are many, both OTC and prescription.

Answered 4/12/2021

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