U.S. doctors online nowAsk doctors free
A 52-year-old male asked:

Is silenor a new sleep medication and is it similar to ambien (zolpidem)?

1 doctor answer1 doctor weighed in
Dr. Sarah Walton
Pharmacology 8 years experience
For sleep, but....: Silenor is a sleep medication but it works very differently from ambien. Silenor's chemical name is doxepin, this has been used as an antidepressant for many years (at much higher doses 100-300mg/day vs 3-6mg for silenor). It works similar to OTC sleep aids like Benadryl (diphenhydramine) and doxylamine by blocking histamine. Zolpidem works in a more complex way on hormones that regulate sleep.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jul 21, 2017


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.