My father s.creatinine increase from 1.7 to 2.1 during 2months he had htn with paroxysmal afib he took apixaban 2.5*2 is it the cause for this ^?

Long term htn: Your father has hypertension. This causes long standing stress on kidneys and heart. Now he has developed another heart problem which is not uncommon. The medication may be related or it may be from the long standing problem of hypertension. Your dad may need more frequent visits to the doctor during changes and additions of medication. It is good that you are helping.