A member asked:

Can higher doses of effexor (venlafaxine) (above 75mg) cause depression to worsen and/or increase symptoms like anhedonia, lethargy, demotivation, etc.?

A doctor has provided 1 answer
Dr. Jeffrey Levine answered

Specializes in Family Medicine

Not typically: Increasing Effexor (venlafaxine) dose may not be effective and can increase side effects, including anxiety, but should not actually worsen depressive symptoms you describe. Effexor (venlafaxine) can unmask Mania in a patient with underlying Bipolar disorder.

Answered 7/2/2016

1.2k views

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