I thought had pus filled calluses on my ankle after a closer look i noticed that its a clear liquid that comes out and there getting bigger?

Unclear question: If your shoe or something else is rubbing the involved skin, you need to change the shoe or whatever may be causing friction. Do not pop the blister. If it pops on its own apply some Neomycin ointment. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine.