I am on 600mg lyrica (pregabalin). i reduced it for the last week to 450mg.i am very irritable. could it be the reduction. thanks?

Maybe (not) . . .: Answer depends upon why you're taking Lyrica (pregabalin) (pregablin), which has many uses, including seizures, neuropathic pain, fibromyalgia & (off-label) behavioral issues. Check out http://www.drugs.com/lyrica.html. So depending upon why you're taking Lyrica (pregabalin), dropping dose may allow underlying condition to manifest itself; perhaps increased irritability from increased pain on lower dose. Discuss w/your doc

It could be!: Dose reduction can be the cause!