A member asked:

I may need cephalosporin therapy with a suspected penicillin allergy. how does it work? do i take a 3rd generation by mouth and sit in an er waiting room with a buddy and an epipen (epinephrine)?

3 doctors weighed in across 2 answers
Dr. Hunter Handsfield answered

Specializes in Infectious Disease

Don't overreact: Allergies to cephalosporins are very rare, even in people with penicillin allergy. I doubt it is necessary to stay in an emergency room or even a doctor's office, or to have an WpiPen at hand. Discuss with the doctor prescribing the antibiotic.

Answered 4/21/2016

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Penicillin allergy: Among all patients reporting penicillin allergy, 85 to 90% will tolerate a penicillin, either because they were never allergic or because they had an earlier allergy that subsequently resolved. Among penicillin skin test-positive patients, approximately 2% will react to a cephalosporin.

Answered 11/28/2017

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