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A 35-year-old member asked:

Can peptic ulcer disease lead to cancer?

2 doctor answers5 doctors weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
Rarely: Peptic ulcers and stomach cancer are both caused, in part, by helicobacter infection. A stomach cancer may present as an ulcer. A bona fide peptic almost never turns into cancer.
Dr. Shaban Faruqui
Specializes in Gastroenterology
Hp -Pud-CA in some: H. pylori infection can lead to chronic gastritis, atrophy of mucosa, and fibrosis with intestinal metaplasia, this change increase risk of Cancer, in addition genetic susceptibility contributes.H.pylori is strongly linked to gastric cancer and is now classified as a group I carcinogen.Of interest H. pylori infection may protect against esophageal adenocarcinoma through reduction in gastric acid
Dr. Shaban Faruqui
Specializes in Gastroenterology
Provided original answer
Gastric ulcer disease and gastric cancer have etiologic factors in common. A likely cause of both is atrophic gastritis induced by H. pylori. By contrast, there appear to be factors associated with duodenal ulcer disease that protect against gastric cancer.Helicobacter pylori infection is now recognized as an important causative factor in both duodenal ulcers and gastric cancer.
Apr 5, 2019

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A 44-year-old member asked:

What can lead to my peptic ulcer?

1 doctor answer2 doctors weighed in
Dr. Yash Khanna
Family Medicine 57 years experience
H Pylori Infection: Peptic ulcer is most commonly caused by infection with a bacteria called H Pylori.Other rare causes may be use of NSAIDs like ibuprofen,naproxen when used regularly.other meds like Actonel, (risedronate)fosamax,pottasium supplements may rarely cause ulcer in stomach. People who smoke and drink alcohol excessively are at increased risk to develop Peptic Ulcer

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Last updated Apr 6, 2019
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