Which is better and more safe in general for treating hypertension and atrial fibrillation metoprolol succinate or bisoprololesp. if s.creatinine1.56

Neither. In clinical: trials, carvedilol has significantly better outcomes than either metoprolol (e.g. 3%/yr lower mortality rates continuing for many years) or bisoprolol. Creatinine is quite another issue, produced by all muscle cells, yet used to crudely estimate renal filtering function, not the 4 known responses to carvedilol. Also the clinical trial data for all the Beta blockers is as augmenters to ACEI agents.