Is it safe to combine ibuprofen and acetaminophen regularly?

It should be safe.: Ibuprofen and acetaminophen have very little interaction with each other. If you are taking them for pain relief after surgery or an injury, it may be more effective to alternate them 3 hours apart. However, ibuprofen should be taken with caution if you have kidney issues. The same goes for acetaminophen if you have any liver problems.