HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

Hi, i just started taking zoloft (sertraline) yesterday (25 mg) and came down with a headache because of the lack of my daily caffeine. can i take a couple motrin?

A doctor has provided 1 answer

Useful: Many headaches respond well to ibuprofen (brand name Motrin) so taking 200-400 mg (usually two pills) is worth a try to minimize your headache. It will not interact with Zoloft (sertraline) so the two can be taken together.

Answered 3/29/2021

1.9k views

Thank

Related Questions

A member asked:

If you take Zoloft (sertraline) can you drink sodas with caffeine? No further details

A doctor has provided 1 answer

A member asked:

Zoloft (sertraline) increase 100to150; change due to still having some anxiety but doing much better; can increase cause jittery/wired feeling;no caffeine?

A doctor has provided 1 answer

A member asked:

Can I take 600mg of ibuprofen 3x/day for 1 wk. if I have GERD & eosinophilic esophagitis? I take 40mg prilosec & 100mg Zoloft (sertraline) daily.

A doctor has provided 1 answer

A member asked:

If i'm on Zoloft and wellbutrin (bupropion) and I take motrin (an nsaid) will I get stomach bleeding?

6 doctors weighed in across 2 answers

A member asked:

What is the best anti nausea plus anti vomiting med. for adults during stomach virus? (tablet form). Can I take it while on Tylenol/Motrin, Zoloft and Metformin?

3 doctors weighed in across 2 answers

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

Can i take a ibuprofen 800mg with Zoloft (sertraline) because of the headache side effect?
What if I have been taking Zoloft (sertraline) for 7 years and been geting headaches so i was taking ibuprofen my doc tells meits bad?
Mild headache for 1 week. Recently stopped d Zoloft (sertraline) 150mg, Very stressed, lack of sleep. I's it brain tumor ?
Hi! I am on 50mg of Zoloft (sertraline) and started to take caffeine free hydroxycut today. will they interact?
Can i take n.O.-xplode caffeine free, when i'm taking zoloft (sertraline).

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.