How can the long term use of adderall (dextroamphetamine and racemic amphetamine) affect the brain?

Numerous ways: Using Adderall (dextroamphetamine and racemic amphetamine) over an extended period can increase the risk of critical cardiovascular problems and strokes. There are also significant mental health issues associated with the long-term use of adderall, (dextroamphetamine and racemic amphetamine) such as depression, hostility and paranoia. In children, protracted use of Adderall (dextroamphetamine and racemic amphetamine) may inhibit growth.