A member asked:

What is the connection between thorazine (chlorpromazine) and irritation of the vagus nerve that causes hiccups. ?

A doctor has provided 1 answer
Dr. Edward Kuhnley answered

Specializes in Child Psychiatry

Mayo clinic notes: the most common cause of long-term hiccups is damage to or irritation of the vagus nerves or phrenic nerves, which serve the diaphragm muscle. Neurotransmitters involved in the process of hiccup include both dopamine (D) and gamma-aminobutyric acid (GABA). Thorazine (chlorpromazine) is a dopamine blocker. Prolonged hiccup requires medical eval to determine cause. Best regards.

Answered 1/30/2019

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