A member asked:

I had surgery & was given oxicodone for pain. the next morning i could hardly talk or swallow. am i allergic to this medicine? my doc was surprised.

A doctor has provided 1 answer

Dr. James Rotchford answered

Specializes in Addiction Medicine

Histamine release: In some patients opiates cause a release of histamine from mast cells. This is particularly prominent with initial dosing. That is why some will start itching. This is not an allergic response but rather a sensitivity as with some patients get seriously constipated and others hardly any effect with opiates.

Answered 8/17/2015

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A member asked:

I had surgery & was given oxicodone for pain. the next morning i could hardly talk or swallow. am i allergic to this medicine? my doc was surprised.

A doctor has provided 1 answer

Dr. James Rotchford answered

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