If spleen is removed does the liver take over all functions or do any of the serious functions get lost? also since liver works more, overstressed?

Not the liver: The major problem is a impaired immune response to capsulated bacteria and perhaps certain parasites. Thus getting pneumococcal vaccines regularly (Prevnar & Pneumovax) is essential. Getting treated early for bacterial infection is another approach. Most people without a spleen can live a normal life with the proper precautions.

Liver And spleen: They have different function though both organs have immune function with spleen being a key organ as a part of the immune system. Vaccination is key before removal of spleen against certain organism. In some patients abs prophylaxis may be needed. Take to your MD.

Not completely, & no: There is much duplication within the immune system. That said, the spleen is important, especially for handling certain bacteria. Special vaccinations should be given, if not before, definitely after splenectomy. Liver also is part of the reticulo-endothelial system, but it will work just fine if the spleen has to be removed.