A member asked:

I take benadryl (diphenhydramine) everyday about 250mg not at once but during the day for chonic allergies. been doing this for two years will this damage my liver?

5 doctors weighed in across 2 answers
Dr. John Chiu answered

No: But it will likely make you less agile and alert. Constipation may also happen for some people.

Answered 5/4/2016

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No, but...: That is really a lot of benadryl (diphenhydramine) and while it will not damage your liver it can have a lot of side effects such as fatigue, dry mouth, constipation and mental slowing. Discuss a change to a non-sedating antihistamine, nasal saline and some nasal steroids with your doctor and try to get off this large dose of benadryl (diphenhydramine). Singulair may also be helpful.

Answered 10/23/2016

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