A member asked:

Which is safer estradiol pellet or pill? pellet less chance for clotting probs? better absorption? trying to decide read pellet is safer in general

A doctor has provided 1 answer
Dr. Cynthia Frazier answered

Specializes in Gynecology

Transdermal : Is the preferred route for estradiol administration because it avoids the liver's first pass. The patch is the most commonly used form of transdermal. I personally like pellets but would recommend a trial of patches first. Once the pellets are placed they are there for 3-4 months. A patch can be removed at any time.

Answered 6/28/2015

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