I suffer from generalized anxiety with dep through the years zoloft,lexapro (escitalopram) and effexor(because of bp) lost efficacy.is there anything else i can take?

Yes - but what: non-pharmacological measures have you used? Have you tried cognitive behavioral therapy? Behavior Modification? Individual psychotherapy? Group psychotherapy? Qi Gong? Tai Chi? Acupuncture? Acupressure? Homeopathy? meditation? Yoga? Exercise program? Breathing exercises? Progressive muscle relaxation? Don't just rely on meds to get rid of your symptoms. Take an active role in eliminating anxiety.

Therapy?: Have you yet tried any form of psychotherapy? Typically, the optimal combination of things to treat emotional issues such as anxiety or depression is medication (which, on your best day, is supposed to take the edge off symptoms) but the real gruntwork takes place in psychotherapist's consulting room.

ANXIETY: Best to discuss medication with your Psychiatrist. If uncomfortable with your Dr. consult another for a second opinion. Have a physical exam by a Dr. to determine if you have a physical illness. Consult with a Clinical Psychologist for psychotherapy with ZOOM sessions. Fears and anxiety could be heightened because of the Covid-19 pandemic. Stay safe & hopeful to elevate your immune system.