A 55-year-old female asked:
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When switching from Lexapro (escitalopram) to Zoloft is it common for their to be a down cycle, i.E depression, an how long should the transition take.?

1 doctor answer
Dr. Pamela Pappas
41 years experience in Psychiatry
Not necessarily: If your doctor is changing your medication, it may be because it wasn't serving your needs? Usually changes are made when people's symptoms don't respond, and better results are needed. I wouldn't expect there to be a "down cycle" unless Lexapro (escitalopram) was helping you more than you realized, and zoloft not so much -- or higher dose is needed. Please contact your prescribing doctor about this.
Answered on May 11, 2016

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