Does glucosamine and chondroitin really work?

Yes: The combination of glucosamine and chondroitin has been shown in studies to (1) provide a degree of pain relief in the short term, and (2) trigger growth of new cartilage when taken for at least two years straight. So it can help you pain and reverse some of the chronic damage. You can find this in the health food store. MSM is not necessary and adds to the cost of the product.

Mixed research: Studies have been mixed. In 2010, a trial that included over 600 people with knee osteoarthritis found that pain was relieved for some people, but that over time, the duo was no more effective than placebo. A more recent study again found that benefit was similar to placebo. Evidence is more definitive for low-impact exercise and following the guidance of your MD for pain meds.