Between 150mg ranitidine and 20 mg pantaprazole, which is safest for lifetime maintenance of acid reflux?

Either: Rebound reflux is more common upon stopping a ppi, but both are considered safe with their own constellation of potential mild interactions with other medications. Ranitidine can cause mental confusion in the context of liver or kidney disease. PPI's can be associated with small increase risk GI infections and a decrease in vitamin/mineral absorption. Ranitidine slightly safer, but not as effectiv